Sesame Oil Administration Does Not Alter Hematologic and Metabolic Parameters in Female Rats

Reports relating to effect of sesame oil intake on various hematologic and metabolic parameters in humans or animals are scanty. Hence we have decided us to undertake this study, investigating the effect of this edible oil on above-mentioned parameters in adult female rats Material and Methods: Adult female Sprague Dawley rats were given oral doses of 1 ml, 2 ml and 4 ml sesame oil twice per day in divided doses, for 30 days respectively. Control female rats were given normal tap water. Oral gavage of sesame oil was done continuously for the study period twice daily and at the end of the 30 day study period, animals were lightly anaesthetized with ether and sacrificed to collect blood samples for analysis. Hematologic parameters such as red blood cell (RBC) count, white blood cell (WBC) count, hemoglobin (Hg), platelets, lymphocytes and mean corpuscular hemoglobin concentration (MCHC) were analyzed by a Hematology Blood Analyzer. Metabolic parameters such as cholesterol, triglycerides, urea, uricacid, creatinine and protein were analyzed by specific analytical kits. Levels of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPX) in blood were assessed by specific analytical kits. Statistical analysis of various data from control and study groups was done using a SPSS data analytical package.